Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing

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Interictal Epileptiform Discharges

EEG remains the primary technique in the diagnosis, characterization, and localization of partial seizures. This review examines the significance and character of interictal epileptiform abnormailites, periodic lateralized epileptiform discharges, and ictal patterns in patients with partial epilepsy. Interictal epileptiform discharges are common and assist in the diagnosis and localization of p...

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Interictal epileptiform discharges do not change before seizures during sleep.

PURPOSE Whether interictal epileptiform discharges (IEDs) increase, decrease, or are unchanged before epileptic seizures has implications for the pathophysiology of epilepsy. Prior studies relating IEDs and seizures have not demonstrated a change in IEDs before seizures. However, they have not controlled for changes in the depth of sleep. Our objective was to test the hypothesis that IEDs are r...

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Detection of Interictal Epileptiform Discharges in Eeg

The diagnosis of epilepsy heavily depends on the detection of epileptiform discharges in interictal EEG, the EEG in between two seizures. By visual analysis a physician wants to detect these epileptiform discharges (spikes). Due to the wide variety of morphologies of epileptiform discharges, and their similarity to waves that are part of normal EEG or to artifacts, this detection is far from st...

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The BOLD response to interictal epileptiform discharges.

We studied single-event and average BOLD responses to EEG interictal epileptic discharges (IEDs) in four patients with focal epilepsy, using continuous EEG-fMRI during 80-min sessions. The detection of activated areas was performed by comparing the BOLD signal at each voxel to a model of the expected signal. Since little is known about the BOLD response to IEDs, we modeled it with the response ...

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PURPOSE Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur in the electro- (EEG) and magnetoencephalogram (MEG) in case of focal epilepsy...

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ژورنال

عنوان ژورنال: Brain

سال: 2021

ISSN: 0006-8950,1460-2156

DOI: 10.1093/brain/awab044